Marta Sanvicente García
Marta Sanvicente García

CRISPR-Analytics (CRISPR-A): a platform for precise analytics and simulations for gene editing

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Albert García-Valiente, Socayna Jouide, Jessica Jabara-Wallace, Èric Bautista, Marc Escobosa, Avencia Sánchez-Mejías, Marc Güell

Gene editing characterization with currently available tools does not always give precise relative proportions among the different types of gene edits present in an edited bulk of cells. We have developed CRISPR-Analytics, CRISPR-A, which is a comprehensive and versatile genome editing web application tool and a nextflow pipeline to give support to gene editing experimental design and analysis. The analysis includes mock-based noise correction, spike-in calibrated amplification bias reduction, and advanced interactive graphics. This expanded robustness makes this tool ideal for analyzing highly sensitive cases such as clinical samples or experiments with low editing efficiencies. Therefore, CRISPR-A is ideal to support multiple kinds of experiments such as double-stranded DNA break-based engineering, base editing (BE), primer editing (PE), and homology-directed repair (HDR), without the need of specifying the used experimental approach.

CRISPR-Analytics (CRISPR-A): a platform for precise analytics and simulations for gene editing

CRISPR-Analytics (CRISPR-A): a platform for precise analytics and simulations for gene editing

Community
Marta Sanvicente García
Marta Sanvicente García
Marta Sanvicente García

Marta Sanvicente García

Ph.D. Student at the Universitat Pompeu Fabra

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Poster presenter