MTBseq-nf: Enabling scalable Tuberculosis genomics “big data” analysis through a Nextflow Wrapper

MTBseq is one of the earliest publicly available pipelines for TB genomics and is widely used by the research community. However, its design limits the CPU usage to 8 threads. Using a Nextflow wrapper, we have achieved an optimization of at least 50% for large cohorts of TB genomics data, without altering the baseline tool.